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References

    Home References

    REFERENCES LISTED

    What is PCR? REFERENCES LISTED:

    **001

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604171/

    Esther M. Blessing, Maria M. Steenkamp, Jorge Manzanares,Charles R. Marmar.2015.
    Cannabidiol as a Potential Treatment for Anxiety Disorders.12(4): 825–836. doi: 10.1007/s13311-015-0387-1

    Original article: https://link.springer.com/article/10.1007%2Fs13311-015-0387-1

    Benefits of PCR REFERENCES LISTED:

    **002

    https://www.ncbi.nlm.nih.gov/pubmed/17157290

    Costa B., Trovato A.E., Comelli F., Giagnoni G., Colleoni M. 2007. The non-psychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain. Eur. J. Pharmacol.556:75–83 10.1016/j.ejphar.2006.11.006

    Original article: https://www.sciencedirect.com/science/article/pii/S001429990601257X?via%3Dihub

    **003

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481531/

    Alline Cristina Campos,Fabricio Araújo Moreira,Felipe Villela Gomes,Elaine Aparecida Del Bel,Francisco Silveira Guimarães.2012.
    Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders.367(1607): 3364–3378.
    (doi: 10.1098/rstb.2011.0389)

    *003.5

    https://www.ncbi.nlm.nih.gov/pubmed/16698671

    Weiss L, Zeira M, Reich S, Har-Noy M, Mechoulam R, Slavin S, Gallily R.2006. Cannabidiol lowers incidence of diabetes in non-obese diabetic mice.Autoimmunity.39(2):143-51 (DOI:10.1080/08916930500356674)

    Original article: https://www.tandfonline.com/doi/abs/10.1080/08916930500356674?journalCode=iaut20

    **004

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707667/

    Orrin Devinsky,Maria Roberta Cilio,Helen Cross,Javier Fernandez-Ruiz,Jacqueline French,Charlotte Hill,Russell Katz,
    Vincenzo Di Marzo,Didier Jutras-Aswad,William George Notcutt,Jose Martinez-Orgado,Philip J. Robson,Brian G. Rohrback,Elizabeth Thiele, Benjamin Whalley,Daniel Friedman.2016.
    Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders.doi: 10.1111/epi.12631

    Original article can be found here: https://onlinelibrary.wiley.com/doi/abs/10.1111/epi.12631

    **005

    https://www.ncbi.nlm.nih.gov/pubmed/27010632

    Shoval G1, Shbiro L, Hershkovitz L, Hazut N, Zalsman G, Mechoulam R, Weller A.2016.
    Prohedonic Effect of Cannabidiol in a Rat Model of Depression. Neuropsychobiology.73(2):123-9 (doi: 10.1159/000443890)

    Original Paper: Karger: https://www.karger.com/Article/Abstract/443890

    **006

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481531

    Alline Cristina Campos,Fabricio Araújo Moreira,Felipe Villela Gomes,Elaine Aparecida Del Bel,Francisco Silveira Guimarães.2012.
    Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders. Philos Trans R Soc Lond B Biol Sci. 367(1607): 3364–3378.(doi: 10.1098/rstb.2011.0389)

    Original article: http://rstb.royalsocietypublishing.org/content/367/1607/3364

    **007

    https://www.ncbi.nlm.nih.gov/pubmed/19442536

    Izzo AA, Camilleri M. 2009.
    Cannabinoids in intestinal inflammation and cancer. Pharmacol Res.60(2):117-25. (doi: 10.1016/j.phrs.2009.03.008. )

    Original article: Science Direct: https://www.sciencedirect.com/science/article/abs/pii/S1043661809000838

    https://www.ncbi.nlm.nih.gov/pubmed/18681481

    Appendino G, Gibbons S, Giana A, Pagani A, Grassi G, Stavri M, Smith E, Rahman MM.2008.
    Antibacterial cannabinoids from Cannabis sativa: a structure-activity study. 71(8):1427-30.(doi: 10.1021/np8002673.)

    Original article: Journal of Natural Products:   https://pubs.acs.org/doi/abs/10.1021/np8002673

    **008

    https://www.ncbi.nlm.nih.gov/pubmed/21175589

    Parker LA, Rock EM, Limebeer CL. 2011.
    Regulation of nausea and vomiting by cannabinoids. Br J Pharmacol..163(7):1411-22. (doi: 10.1111/j.1476-5381.2010.01176.x.)

    Original article: British Pharmalogical Society: https://bpspubs.onlinelibrary.wiley.com/doi/abs/10.1111/j.1476-5381.2010.01176.x

    **009

    https://www.ncbi.nlm.nih.gov/pubmed/19442536

    Izzo AA, Camilleri M. 2009.
    Cannabinoids in intestinal inflammation and cancer. Pharmacol Res.60(2):117-25. (DOI:10.1016/j.phrs.2009.03.008)

    **010

    https://www.ncbi.nlm.nih.gov/pubmed/9653194

    These data suggest that anandamide blocks human breast cancer cell proliferation through CB1-like receptor-mediated inhibition of endogenous prolactin action at the level of prolactin receptor.

    **011

    https://www.ncbi.nlm.nih.gov/pubmed/20090845

    Remarkably, cannabinoids applied at high concentration induce apoptosis in all subclones independently of CB(1), CB(2) and AKT, but still through a mechanism involving ERK1/2.

    **012

    https://www.ncbi.nlm.nih.gov/pubmed/16818650

    In addition, cannabinoid treatment inhibited the spreading of pancreatic tumor cells.

    **013

    https://www.ncbi.nlm.nih.gov/pubmed/21097714?dopt=Abstract

    Reduced proliferation and vascularization, along with increased apoptosis, were observed in tumors obtained from animals treated with JWH-133 and Win55,212-2. Upon further elucidation into the molecular mechanism, we observed that both CB1 and CB2 agonists inhibited phosphorylation of AKT, a key signaling molecule controlling cell survival, migration, and apoptosis, and reduced matrix metalloproteinase 9 expression and activity.

    **014

    https://www.ncbi.nlm.nih.gov/pubmed/19690545

    Signalling pathways activated by JWH-015 included JNK (c-Jun N-terminal kinase) activation and Akt inhibition. In vivo treatment with JWH-015 caused a significant reduction in tumour growth in mice.

    **015

    https://www.ncbi.nlm.nih.gov/pubmed/12511587

    n cell culture experiments pharmacological activation of cannabinoid receptors induced the apoptotic death of tumorigenic epidermal cells, whereas the viability of nontransformed epidermal cells remained unaffected. Local administration of the mixed CB(1)/CB(2) agonist WIN-55,212-2 or the selective CB(2) agonist JWH-133 induced a considerable growth inhibition of malignant tumors generated by inoculation of epidermal tumor cells into nude mice. Cannabinoid-treated tumors showed an increased number of apoptotic cells.

    **016

    https://www.ncbi.nlm.nih.gov/pubmed/21475304

    JWH-015 reduced the growth of HCC subcutaneous xenografts, an effect that was not evident when autophagy was genetically of pharmacologically inhibited in those tumors.

    Moreover, cannabinoids were also able to inhibit tumor growth and ascites in an orthotopic model of HCC xenograft. Our findings may contribute to the design of new therapeutic strategies for the management of HCC.

    **017

    https://www.ncbi.nlm.nih.gov/pubmed/19047095

    The effects of the CB1 agonist arachinodyl-2′-chloroethylamide and the CB2 agonist N-cyclopentyl-7-methyl-1-(2-morpholin-4-ylethyl)-1,8-naphthyridin-4(1H)-on-3-carboxamide (CB13) on tumor cell apoptosis and ceramide and tumor necrosis factor (TNF)-alpha production were evaluated.

    **018

    https://www.ncbi.nlm.nih.gov/pubmed/20546877

    Cell death occurred via apoptosis caused by continuous influx of calcium through TRPV2.

    **019

    https://cbdinstead.com/blogs/cbd-and-mental-health/cbd-and-recovering-from-anorexia

    Cell death occurred via apoptosis caused by continuous influx of calcium through TRPV2.

    **020

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874292/

    Additionally, there is also evidence that PCR may reduce the negative psychotropic effects, memory impairment, and appetite stimulation, anxiety and psychotic-like states of THC while enhancing its positive therapeutic actions

    **021

    https://www.projectcbd.org/science/cannabis-pharmacology/cbd-and-parkinsons-disease

    PCR activates a G-coupled protein receptor called “GPR6” that is highly expressed in the basal ganglia region of the brain. GPR6 is considered an “orphan receptor” because researchers have yet to find the primary endogenous compound that binds to this receptor.(1)

    **022

    https://www.dementiacarecentral.com/aboutdementia/treating/cbd/#alzheimers

    Memory loss and other brain deterioration indirectly leads to increased oxygen in the brain. CBD is an antioxidant, which helps reduce the problems associated with oxygen stress. Brain functions negatively impacted by oxygen stress can be improved by using CBD.

    **023

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202504/

    CBD, and some derivatives, were found to cause a selective anxiolytic effect in the elevated plus-maze, within a limited range of doses.

    Is PCR Legal? REFERENCES LISTED:

    Hemp Extract Oil is 100% legal in all 50 states. Under the 2014 Farm Bill, CBD derived from Hemp Seed Oil that has less than 0.3% THC by dry weight is legal. Click the link for a copy of the farm bill HERE.

    What is a farm bill? The Agricultural Act of 2014 aka the Farm Bill is an omnibus legislation passed by the United States Congress. Farm Bills are passed about every five years, creating and reauthorizing federal programs in some different interests. On February 7, 2014, President Obama signed the Farm Bill of 2013 into law. Section 7606 of the act, Legitimacy of Industrial Hemp Research, defines industrial hemp as distinct from marijuana and authorizes institutions of higher education or state department’s of agriculture in states that legalized hemp cultivation to regulate and conduct research and pilot programs. Under this law, a product of the plant can be used and processed as long as the THC (psychotropic aspect) levels are no more than 0.3%. The reason industrial hemp is so popular is it contains low TCH and high compounds of whats called Cannabinoids. Particularly one called CBD (Cannabidiol) and in many governmental studies, including the government’s patent #6630507.

    Section 7606 of the 2014 US Farm Bill

    The isolated Section pertaining to Industrial Hemp:

    https://www.law.cornell.edu/uscode/text/7/5940

    DEA Internal Directive Regarding the Presence of Cannabinoids in Products and Materials Made from the Cannabis Plant

    “Products and materials that are made from the cannabis plant and which fall outside the CSA definition of marijuana (such as sterilized seeds, oil or cake made from the seeds, and mature stalks) are not controlled under the CSA. Such products may accordingly be sold and otherwise distributed throughout the United States without restriction under the CSA or its implementing regulations. The mere presence of cannabinoids is not itself dispositive as to whether a substance is within the scope of the CSA; the dispositive question is whether the substance falls within the CSA definition of marijuana.”

    https://www.deadiversion.usdoj.gov/schedules/marijuana/dea_internal_directive_cannabinoids_05222018.html

    The World Health Organization Report

    “In humans, CBD exhibits no effects indicative of any abuse or dependence potential…CBD is generally well tolerated with a good safety profile…To date, there is no evidence of recreation use of CBD or any public health related problems.”

    https://hempsupporter.com/wp-content/uploads/2018/02/WHO-CBD-report.pdf

    State Industrial Hemp Statutes:

    http://www.ncsl.org/research/agriculture-and-rural-development/state-industrial-hemp-statutes.aspx

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